Careers
Clovis Oncology is looking for dedicated people who are interested in joining a growing organization.
- Senior Scientist, Cancer Biology
- Senior/Principal Scientist, Molecular Diagnostics
- Manager, Pharmaceutical Development
Title: Senior Scientist, Cancer Biology
Reports to: Senior Director, Molecular Diagnostics
Department: Translational Medicine
Exempt/Non-exempt: Exempt
Job Location: San Francisco, CA
Role
Reporting to the Senior Director of Molecular Diagnostics, the Senior Research Scientist (SRS) will be responsible for performing cellular and molecular experiments to characterize drug activity and mechanisms of sensitivity/resistance.
The Scientist will initially be involved in the EMSI program but may be required to have responsibilities across
NCE projects.
The key tasks for the SRS initially will include the following:
- Laboratory set up and management of lab activities
- Implementation of in vitro models (biochemical and cellular assays) to support the pre-clinical development of the
EMSI program - Management of academic/commercial collaborations supporting the translational aspects of NCEs
- Development of assays to interrogate optimal combination therapy strategies
- Management of biospecimen collections
- Representation on cross functional project teams
Qualifications
A PhD in molecular biology or related field, with at least five years of research experience in cancer biology or related field is required. Possessing an enthusiasm for personalized medicine, he or she will have demonstrated success in the field of cancer biology with a focus on drug development. The ideal candidate will have hands-on experience in molecular and cellular biology with working knowledge of pre-clinical cancer drug development, including:
- Demonstrated experience (peer reviewed publications) in cancer drug development is required.
- Experience with designing, executing, and analyzing data from molecular and cell-based experiments is required.
- Experience with defining mechanisms of drug sensitivity and resistance is required.
- In vitro pharmacology experience is strongly preferred.
- Experience with FACS analysis is preferred.
- Experience in running a molecular/cellular lab is preferred including ordering and maintaining lab equipment
and reagents. - Experience in tyrosine kinase inhibitors is strongly preferred.
- Strong organizational skills, ability to prioritize and multi-task.
- Excellent verbal and written communication skills.
Personal Profile
The Scientist will be a dynamic and innovative cancer drug development biologist with a well-developed sense of teamwork. He or she will have the interpersonal skills required to communicate effectively with collaborators and compound development teams.
Title: Senior/Principal Scientist, Molecular Diagnostics
Reports to: Senior Director, Molecular Diagnostics
Department: Translational Medicine
Exempt/Non-exempt: Exempt
Job Location: San Francisco, CA
Role
Reporting to the Senior Director of Molecular Diagnostics, the Scientist will be responsible for pre-clinical evaluation of the EMSI. The Scientist will also perform
The key tasks will initially include (at least) the following:
- Evaluation of molecular diagnostic approaches using minimally invasive blood-based matrices such as circulating
tumor cells, cell-free nucleic acid, and tumor-derived exosomes. - Evaluation of different molecular platforms including SARMS, PNA-LNA-PCR, sequencing approaches.
- Initiation and management of academic collaborations to support technical feasibility studies in NSCLC and
pancreatic cancer. - Representation on cross-functional project teams.
Possessing the ability to interface with cross-functional teams, the Scientist will work effectively with Clinical, and Operations groups to assist in the preparation and implementation of Biomarker plans within clinical studies. The candidate will also drive the design and execution of appropriate pre-clinical studies in support of compound-specific Biomarker strategies. He/she will analyze and interpret study data, and prepare reports for internal submission and publication, where appropriate. The ability to develop and manage strategic collaborations with key third parties including academic and commercial vendors is an important element of the role.
Qualifications
A PhD in molecular biology or related field, with at least five years of research experience in cancer genetics and/or cancer medicine is required, preferentially in the diagnostics/biotechnology industry. Possessing expertise in molecular diagnostic development and an enthusiasm for personalized medicine, he or she will have demonstrated success in the field of oncology with an ability to leverage cutting edge technology platforms. The ideal candidate will have hands-on experience in molecular biology, and management of laboratory activities including:
- Experience with designing, executing, and analyzing data from molecular and cell-based experiments is required.
- Experience developing companion diagnostic assays is required (eg qPCR, IHC).
- Experience with managing and analyzing clinical trial samples is preferred.
- Understanding of analytical and clinical validation procedures for companion diagnostics is required.
- Experience in managing a molecular/cellular lab is preferred including ordering and maintaining lab equipment
and reagents. - Understanding of Occupational Health and Safety regulations is preferred.
- Strong organizational skills, ability to prioritize and multi-task.
- Excellent verbal and written communication skills.
Personal Profile
The Scientist will be a dynamic and innovative cancer biologist with expertise in developing molecular diagnostics. He or she will have the interpersonal skills required to communicate effectively with a first-rate scientific team, playing a critical role in the co-development of companion diagnostics to support the development of exciting new therapies in the treatment of cancer.
Title: Manager, Pharmaceutical Development
Reports to: Senior Director, Pharmaceutical Development
Department: Technical Operations
Exempt/Non-exempt: Exempt
Job Location: Boulder, CO or San Francisco, CA
Role
The Manager, Pharmaceutical Development position will be responsible for definition and management of contractor activities related to development and manufacturing of drug substances and/or drug products, and development and validation of analytical methods. The scope of work will support products all stages of development up to and including commercialization. Some travel, possibly international, will be required.
Responsibilities will include:
- Identification and resolution of technical challenges in the areas of drug substance process development and manufacturing, drug product formulation development, drug product process development and manufacturing, analytical method development, and technology transfer
- Creation and execution of CMC development plans for new products
- Creation and execution of process (drug substance and drug product) and analytical method validation plans
- Identification and management of contract research and contract manufacturing organizations to support product development
- Coordination with supply chain and clinical operations groups for production of clinical trial materials
- Assistance in batch record review
- Assistance in deviation investigations
- Assistance in the preparation and review of regulatory documentation
- Assistance in due diligence technical assessments of potential new products
Qualifications
- College degree, BA or BS in science or relevant field
- More than 7 years of direct experience with pharmaceutical product development
- Thorough understanding of regulatory requirements for pharmaceutical products in US and EU
- Thorough understanding of cGMP requirements for pharmaceutical products
- Strong organizational, analytical and interpersonal skills
- Ability to work in a fast paced dynamic environment with multiple projects
If you would like to submit a resume for our files, please send a resume and a cover letter to: careers@clovisoncology.com